Obtaining DNA crystal samples of the drug, once validated by Harry P. de Koning, researcher at the

CD27 is free drug patent to allow the free market in the future synchrotron light demonstrates the efficiency of a new drug against lights albums malaria Researchers from the Polytechnic University of Catalonia BarcelonaTech lights albums (UPC), on the Institute of Medical Chemistry (IQM-CSIC) and the University of Glasgow have shown that CD27 represents an alternative drug in the treatment of malaria. To achieve this, they analyzed the crystal structure of the DNA with the drug CD27 from X-ray diffraction experiments lights albums at ALBA Synchrotron. The research was published lights albums in the journal Acta Crystallographic D '.
An international group of researchers, led by Lourdes Campos, Department of Chemical Engineering of the UPC, CD27 has shown that the drug may be an option lights albums in treating malaria, based on the study of the 3D image the crystal structure of a complex of DNA and drug. The drug CD27 is a compound synthesized by researchers at the Institute of Medical Chemistry, National Research Council (IQM-CSIC) in Madrid, led by Christophe Dardonville. "The CD27 is chemically related molecules diamidines two-and-amidines has been previously used successfully against other similar parasites of the genus Trypanosoma, which occurs in Africa 'sleeping sickness' and Chagas disease in North South, lights albums "says researcher Lourdes Campos. The results show how the drug CD27 completely covers the crack of a smaller area of the DNA, thus preventing the normal development of the parasite and causing his death. lights albums This study allows a better understanding of this family lights albums of compounds and can significantly contribute to the development of new drugs more effective against malaria.
Obtaining DNA crystal samples of the drug, once validated by Harry P. de Koning, researcher at the University of Glasgow, were sent to the research group in Crystallography, Structure and Function of Biological lights albums Molecules (MACROM) of UPC led Lourdes Campos. For over a year, the group has worked on obtaining a crystal structure of DNA. Obtaining a crystal multiparameter DNA is a process, ie, needs of different variables. So, before getting a glass of DNA with the drug requires many trials in different conditions. The crystal must present a high order of the molecules in the crystal lattice, which in turn would end the three-dimensional structure of the complex. "Get a good glass work is long and costly and require the collaboration of groups from different disciplines. With the help of new synchrotron ALBA as science advances by leaps and bounds, if compared with 20 years ago, "said Lourdes Campos. In the next phase, the researchers analyzed lights albums crystals of the complex of the drug with DNA, using X-ray diffraction line macromolecules XALOC ALBA Synchrotron. X-rays passing through the crystal and diffract, projected images with signal points, after a series of mathematical analysis, to determine the three-dimensional structure of the molecule. Once the 3D image obtained in the laboratory group MACROM, researchers have identified the details of the structure of CD27. This allows the drug to recognize DNA regions covering the narrow groove or crack under the DNA, which prevents the normal development of the parasite. Also, these studies provide a rationalized design of new drugs considering molecular interactions that generate CD27. The research results have been validated and deposited in the Protein Data Bank, a database of three-dimensional structures of proteins and nucleic acids, and published in the journal Acta Crystallografica D. The drug CD27 is free of patent, with the aim of contributing to a future free marketing of the drug that acts against parasites causing malaria. Thus, the drug can be produced by any pharmaceutical company interested in commercializing it.
Malaria causes over one million deaths per year Malaria is an infectious disease caused by a parasite of the genus Plasmodium, which is transmitted through the bite of a mosquito. It affects mainly African countries, but also in parts of Latin America and Asia (with a 3.4 billion population at risk, according to the World Health Organization). Estimated lights albums to cause more than one million deaths per year and parasite resistance to drugs that have been developed so far represents lights albums an obstacle in the treatment of disease.
The ALBA Synchrotron ALBA is the only synchrotron light source that exists in Spain. It is a complex ACCEL